EGCG - Dr. Hal Chapman

EGCG (Epigallocatechin-3-gallate) is a compound found in green tea that has anti-fibrotic, anti-inflammatory, and antioxidant effects. A pilot study supported by Three Lakes Foundation demonstrated that EGCG markedly attenuated pro-fibrotic signaling and new collagen accumulation in lung tissue obtained from IPF patients.

The data were published in J. Clin Invest: A fibroblast-dependent TGF-B1/sFRP2 noncanonical Wnt signalin axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis”.

pubmed.ncbi.nlm.nih.gov

A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis - PubMed

Reciprocal interactions between alveolar fibroblasts and epithelial cells are crucial for lung homeostasis, injury repair, and fibrogenesis, but underlying mechanisms remain unclear. To investigate, we administered the fibroblast-selective TGF-β1 signaling inhibitor epigallocatechin gallate (EGCG) t …

The results from this work were used to obtain additional funding for a Phase I clinical trial to assess the safety and efficacy of oral EGCG in IPF patients. The trial is currently ongoing.

https://clinicaltrials.gov/study/NCT05195918?cond=fibrosis&intr=EGCG&rank=3

A substudy using collagen-targeted PET to measure effect of ECGC on collagen

deposition is also in progress:

https://clinicaltrials.gov/study/NCT06265532?cond=fibrosis&intr=EGCG&rank=2